European Pharmacoepidemiology Network for Monitoring the Benefit and Risk of Medical Products (Italy)

Research Areas:
Our Regional Health Authority manages a large database that covers drug prescription records from community pharmacies and hospital discharge records. The linkage is performed through an individual anonymous identifier. The data collection is longitudinal, is updated regularly (drug records monthly and hospital based records on a 6 months basis) and goes back to 1993. Regional Cancer Registry and the Registry of mortality data are also available. On the grounds of the reported  data different epidemiological studies has been performed.
The construction of a computerized database of laboratory data on a regional scale is underway and will be integrated to the record linkage system.


Role of partner sought: research, training

ITN (Italy)

Research Areas:
Oncologic
Imaging/radiotherapy
Biotherapy (including regenerative medicine)
Pathobiology (including biomarkers)
Oncogenomics
Cancer immunology
Bioinformatics and Structural biology
Molecular and Cell Biology

Role of partner sought: technology development, research, training

extracorporeal bone generation (Israel)

Research Areas:
ex vivo bone generation for bone graftong

mechanotransduction in human cells



Role of partner sought: technology development, research

DEVELOPMENT OF A NEW POINT-OF-CARE DIAGNOSTIC TEST FOR THE EARLY DETECTION OF BACTERIAL INFECTION IN NEWBORN INFANTS (Spain)

Research Areas:
BIOSENSOR Developers
o   Electronic (one partner sought)
o   Optics (one partner sought)
o   PCR. (one partner sought)
Clinical analysis equipment developer or manufacturer.
Distributor.
Informatics system developer


Role of partner sought: technology development, research

Drug and gene delivery systems (Israel)

Research Areas:
drug delivery systems, gene and siRNA delivery and therapy, nanoparticles, liposomes, targeted delivery systems, animal models of cardiovascular, cancer, and bone pathologies.



Role of partner sought: technology development, research, dissemination, demonstration

Proposal on the use of the SELEX methodology for generating druglike molecules for traditional (protein) targets. (Italy)

Research Areas:
Together with five European partners we are developing a project aimed to the rapid discovery of low molecular weight drug molecules inhibiting proteins related to the formation and progression of cancer and related diseases using the SELEX method.
We intend to characterize the gene functions involved in the development of human disease, particularly cancer, by rapid design of selective inhibitors of the translational end-products. Unlike to siRNA-based approaches, the relevance of the final protein target could be analyzed. Our proposal consists of a new approach to design selective drug-like inhibitors, which may be leads for future therapeutic approaches in short time periods allowing high throughput characterizations of gene products. Our method would not only give us leads in a much shorter period than conventional lead-finding methods, but also provide means to scale-up the synthesis of those leads, stemming from our process, in a selective and proprietary fashion.
To accomplish this goal, research groups with expertise in the fields of medicinal, combinatorial (dynamic combinatorial libraries), and organic chemistry, biochemistry biophysics, as well as membrane reactor technology have been assembled.
We are looking for expertise in the field of protein production, and biological screening for our leads to cancer-related targets.

We are interested in (preferentially) corporate partners, who could provide us with proteins being targets for the intervention of cancer and biological assays for the characterization of our leads.


Role of partner sought: technology development, research, training, dissemination, demonstration

New algoritms for large medical data management (Estonia)

Research Areas:
Data management, software development

Role of partner sought: technology development

Mapping trends of HIV in Europe (Estonia)

Research Areas:
Epidemiology of sexually transmitted diseases including HIV.

Role of partner sought: research, dissemination, other

Development of tools for sensitive and specific in vitro detection of proteins and their interactions for diagnostic, prognostics and monitoring purposes (Austria)

Research Areas:
cancer and inflammation,
prostate cancer, signal transduction, NF-kappa B

Role of partner sought: technology development, research, training

NON-INVASIVE ELECTRORHEOLOGICAL METHODS AND TECHNIQUES FOR INVESTIGATION MOLECULAR AND CELLULAR INTERACTIONS OF BLOOD FORMED ELEMENTS AND BLOOD SOLUBLE DRAG-REDUCING POLYMERS (Bulgaria)

Research Areas:
MOLECULAR AND CELLULAR INTERACTIONS OF BLOOD FORMED ELEMENTS,NON-INVASIVE METHODS AND TECHNIQUES,  BLOOD SOLUBLE DRAG-REDUCING POLYMERS, HEMORHEOLOGY, HEMODYNAMICS, ELECTRORHEOLOGY, hemorheological disturbances in PATIENTS WITH CEREBROVASCULAR DISEASE, IN PREGNANT WOMEN WITH HYPERTENSION OR PRE-ECLAMPSIA



Role of partner sought: technology development, research, training, dissemination, other